May 20th, 2018

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Histomorphometric Alterations Induced in the Testicular Tissues by Variable Sizes of Silver Nanoparticles
Authors:  Mansour Almansour, Ph.D., Qais Jarrar, M.Sc., Abdelkader Battah, Ph.D., and Bashir Jarrar, Ph.D.
  OBJECTIVE: To investigate the histomorphometric alterations induced in testicular tissues by variable sizes of silver nanoparticles (SNPs).

STUDY DESIGN: Male mice (BALB/C) were treated with SNPs (1 mg/kg) using 5 different sizes (10, 20, 40, 60, and 100 nm) for 35 days. Testicular biopsies from all mice under study were examined histomorphologically.

RESULTS: SNPs sized 10 and 20 nm had provoked morphometric changes in the testes of the subjected mice together with the following histological alterations: seminiferous tubules, degeneration, spermatocyte cytoplasmic vacuolation, spermatocyte sloughing, and spermatid giant cell formation. Larger SNPs (40, 60, and 100 nm) induced little or no testicular histomorphometric alterations.

CONCLUSION: The findings of the present work may indicate that subchronic exposure to SNPs could have a deleterious impact on the testicular tissues and spermatogenic process that could affect fertility and reproduction, with smaller SNPs being more toxic than larger ones.
Keywords:  morphometric alterations, nanocrystalline materials, nanocrystals, reproduction, seminiferous tubules, silver, silver nanoparticles, spermatid giant cells, spermatids, spermatoblasts, spermatogenesis, testes
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