July 21st, 2018

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Effect of Follicular Flushing in Poorest-Responder Patients During in Vitro Fertilization Cycles
Authors:  Ahmet Zeki Isik, M.D., and Funda Gode, M.D.
  OBJECTIVE: To determine the efficacy of follicular flushing in poorest-responder patients during in vitro fertilization cycles.

STUDY DESIGN: Poorest controlled ovarian hyperstimulation responders who were undergoing in vitro fertilization–intracytoplasmic sperm injection with a gonadotropin-releasing hormone antagonist protocol were included. Poorest response was defined as having ≤5 follicles of ≥12-mm diameter on the day of human chorionic gonadotropin administration. Direct aspira-tion versus flushing during oocyte retrieval were compared.

RESULTS: In total, 137 patients were enrolled (direct aspiration group, n=84; flushing group, n=53). There were no significant differences between the two groups in terms of the number of retrieved oocytes (2.85±1.45 vs. 3.14±1.53), implantation rate (13.79% vs. 18.18%), clinical pregnancy rate (11.9% vs. 18.9%), or live birth rate (5.9% vs. 11.3%).

CONCLUSION: Follicular flushing during oocyte retrieval does not affect the cycle outcome in poorest-responder patients.
Keywords:  assisted reproductive technology; direct aspiration; follicle-stimulation hormone; follicular flushing; in vitro fertilization; infertility; live-birth pregnancy rate; ovarian follicle; poorest responders; pregnancy rates
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