July 21st, 2018

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Value of Transferring Day 5 Blastocyst Generating from a Low-Quality Day 3 Embryo
Authors:  Xin Chen, M.D., M.Sc., Li-Juan Xu, M.D., Xiao-Long Tian, M.D., Yu-Dong Liu, M.D., Ping-Ping Guo, M.D., De-Sheng Ye, Ph.D., and Shi-Ling Chen, M.D., Ph.D.
  OBJECTIVE: To determine the value of transferring a day 5 (D5) blastocyst generated from a low-quality day 3 (D3) embryo in the subsequent frozen embryo transfer cycle after using the freeze-all policy.

STUDY DESIGN: A retrospective case-control study was conducted between January 2013 and June 2015 at a university-affiliated fertility center in China. The current study analyzed vitrified-warmed embryo transfers of D5 blastocysts generated from low-quality D3 embryos (D5-LQ).

RESULTS: Although the high-quality D3 embryo (D3-HQ) group transferred more embryos than did the D5-LQ group (2.1±0.3 vs. 1.7±0.5, respectively; p<0.001), the implantation rate, clinical pregnancy rate, miscarriage rate, and live birth rate in the D5-LQ group was comparable to that of D3-HQ group. Furthermore, a logistic regression analysis showed that the embryo type and number of embryos transferred were not independently associated with pregnancy outcomes.

CONCLUSION: Transfer of D5 blastocysts generating from low-quality D3 embryos results in normal pregnancy rates and live birth rate. This information will help clinicians by allowing a more flexible schedule.
Keywords:  blastocyst, blastocyst transfer, embryo, freeze-all policy, frozen embryo transfer, in vitro fertilization, pregnancy outcomes, single embryo transfer, tubal embryo stage transfer, tubal embryo transfer
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