October 18th, 2018

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Bolus Fentanyl Coadministered with Target-Controlled Infusion of Propofol for Oocyte Retrieval
Authors:  Demet Coskun, M.D., Berrin Gunaydin, M.D., Ph.D., Ayca Tas Tuna, M.D., Hulya Celebi, M.D., Kadir Kaya, M.D., and Ahmet Erdem, M.D.
  OBJECTIVE: To investigate whether administration of 1 or 1.5 μg/kg of fentanyl before onset of target-controlled infusion (TCI) of propofol would be an effective and satisfactory analgesic regimen when hemodynamic parameters, pain, sedation, and recovery scores are compared during transvaginal ultrasound-guided oocyte retrieval.

STUDY DESIGN: Forty women were scheduled for oocyte retrieval in the present randomized prospective study. Following standard monitorization, patients were randomly allocated to receive either intravenous (IV) bolus fentanyl 1 μg/kg (Group I, n=20) or 1.5 μg/kg (Group II, n=20). Afterwards, TCI propofol at effect site concentration (Ce) 1.5 μg/mL was started and then maintained by adjusting propofol dose due to pain intensity according to numeric rating scale. Hemodynamic variables and sedation scores were recorded every 5 minutes throughout the procedure.

RESULTS: Demographic properties and duration of anesthesia and procedure were comparable between the groups. The number of patients requiring dose adjustment was similar between the groups (25% and 30% in groups I and II, respectively).

CONCLUSION: We demonstrated that IV bolus administration of fentanyl, either 1 or 1.5 μg/kg with TCI of propofol at Ce 1.5 μg/mL, provided similarly satisfactory conscious sedation and analgesia without changing hemodynamics, recovery profile, and side effects during oocyte retrieval.
Keywords:  adjuvants, anesthesia; analgesics, opioid; anesthetics, intravenous; assisted reproductive techniques; fentanyl; narcotics; oocyte retrieval; propofol; target controlled infusion
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