October 18th, 2018

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Effect of Day 3 or 5 Embryo Transfer on Pregnancy Rates and Perinatal Outcomes: Evaluation of 1,291 ICSI/IVF Cycles
Authors:  Özgür Tökmeci, M.D., Muammer Dogan, M.D., Hasan Onur Topçu, M.D., Özgür Demirel, M.D., and Ali Irfan Güzel, M.D.
  OBJECTIVE: To evaluate the impact of day 3 (D3ET) or 5 embryo transfer (D5ET) on the pregnancy rates and perinatal outcomes in intracytoplasmic sperm injection/in vitro fertilization (ICSI/IVF) cycles.

STUDY DESIGN: A total of 1,291 ICSI/IVF cycles (1,188 patients) were evaluated in this retrospective study.

RESULTS: Average gonadotropin dose used, estradiol (E2) level on the day of human chorionic gonadotropin (hCG) injection, number of oocytes picked-up, mature oocytes, fertilized oocytes, and embryos transferred were statistically significant between groups. hCG positivity, clinical pregnancy rate, fertilization rate, twin pregnancy rate, triplet pregnancy rate, and live birth rate were higher in the D5ET group, but the differences between all these parameters were not statistically significant. Implantation rate was higher in the D5ET group, and this difference was found to be statistically significant (p<0.005). Patients age ≥35 had statistically significantly lower numbers of oocytes picked up, mature oocytes, and fertilized oocytes (p<0.05). However, no statistically significant difference was found among implantation rates, clinical pregnancy rates, multiple gestation rates, and live birth rates (p>0.005).

CONCLUSION: Transfer of lower numbers of blastocyst embryos with a high implantation rate can decrease the rates of multiple pregnancies without reducing the rates of clinical pregnancies.
Keywords:  assisted reproductive techniques, embryo transfer, in vitro fertilization, intracytoplasmic sperm injection, perinatal outcomes, pregnancy outcomes, pregnancy rates, reproductive technology
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