February 22nd, 2019

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Changes in the Gestational Ages of Complete and Partial Moles Over 35 Years at Two Hospitals
Authors:  Kamba Ryu, M.D., Hideo Matsui, M.D., Ph.D., Toshiyuki Kanno, M.D., Hirokazu Usui, M.D., Ph.D., and Makio Shozu, M.D., Ph.D.
  OBJECTIVE: To compare trends in the gestational ages at which single complete hydatidiform moles (CHMs) and partial hydatidiform moles (PHMs) were evacuated, and the rates of postmolar gestational trophoblastic neoplasia (GTN) between 1980 and 2014 at 2 hospitals.

STUDY DESIGN: We retrospectively studied 1,334 patients with single CHMs or PHMs. The patients’ medical records were evaluated, and the patients were assigned to 7 periods: group A: 1980–1984, group B: 1985–1989, group C: 1990–1994, group D: 1995–1999, group E: 2000–2004, group F: 2005–2009, and group G: 2010–2014.

RESULTS: The number of postmolar patients gradually declined over the 35-year period. The gestational ages at CHM and PHM evacuation were 12.3±3.7 weeks from 1980–1984 and 9.1±0.91 weeks from 2010–2014, and 12.6±3.7 weeks from 1980–1984 and 10.3±3.4 weeks from 2010–2014, respectively. The GTN rate was fairly constant during the 35-year period (18.9–37.5%).

CONCLUSION: The widespread use of ultrasonography has led to earlier CHM and PHM diagnosis and evacuation. The median gestational ages at CHM and PHM evacuation declined, while the rate of GTN after CHM evacuation did not decline over the 35-year period.
Keywords:  gestational age, gestational trophoblastic neoplasia; hydatid mole; hydatidiform mole, complete; hydatidiform mole, partial; molar pregnancy; pregnancy, molar
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