December 19th, 2018

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Title:
Sleep Disturbance and Ovarian Stimulation Outcomes in Infertility and Fertility Preservation Patients
Authors:  Brianna M. W. Lyttle, M.D., Angela K. Lawson, Ph.D., Susan Klock, Ph.D., Kristin Smith, B.S., Ralph Kazer, M.D., Jennifer Hirshfeld-Cytron, M.D., and Mary Ellen Pavone, M.D., MSCI
  OBJECTIVE: To assess sleep patterns and ovarian stimulation outcomes in infertile as compared to fertility preservation (FP) patients with a concurrent cancer diagnosis undergoing controlled ovarian hyperstimulation (COH).

STUDY DESIGN: Prospective survey study done at a single academic medical center examining sleep disturbance, medical diagnoses, anti-Müllerian hormone (AMH), and COH stimulation results using CES-D scale in 50 infertile and 32 age-matched FP patients.

RESULTS: Sleep disturbance was significantly higher at baseline in FP patients. Over time, sleep disturbance significantly increased in infertile patients (T1 MOS-SS SCORE= 16; T2 MOS-SS SCORE=20) but not in FP patients (T1 MOS-SS SCORE=32; T2 MOS-SS SCORE=36). Sleep disturbance did correlate with CES-D scores for both infertile and FP patients. However, no correlations were found between sleep disturbance and AMH, peak estradiol, total medication received, number of oocytes retrieved, and number of oocytes frozen.

CONCLUSION: Sleep scores for infertile patients significantly increased, often reaching values equivalent to national levels cited for chronic illnesses. For both infertile and FP patients, sleep scores correlated with CES-D scores but did not correlate with ovarian stimulation outcomes.
Keywords:  assisted reproduction techniques, controlled ovarian hyperstimulation, infertility, insufficient sleep syndrome, ovarian stimulation, ovulation induction, sleep disorders, sleep disturbance, sleep fragmentation
   
   
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