July 19th, 2019

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Hepatocellular Carcinoma During Pregnancy: A Case Report
Authors:  Jean-Huei Yau, M.D., Daniel Chilcote, M.D., and Catherine Eppes, M.D., MPH
BACKGROUND: Hepatocellular carcinoma (HCC) during pregnancy is extremely rare, with fewer than 50 cases reported in the literature. We present a case of a young nulliparous patient with newly diagnosed advanced HCC.

CASE: A 17-year-old woman, G1P0, at 18.2 weeks’ gestation and with newly diagnosed chronic hepatitis B received a quadruple screen. The results returned with remarkably elevated alpha fetoprotein (AFP), leading to her diagnosis of advanced HCC. Her cancer progressed rapidly during the course of her pregnancy. She delivered a 1,435-g infant at 31 weeks via forceps-assisted vaginal delivery and unfortunately died 21 days later.

CONCLUSION: HCC may be a rare cause of markedly elevated AFP during pregnancy. Pregnancy may lead to rapid progression of this cancer, and maternal and fetal outcomes are poor.
Keywords:  adolescent, chronic hepatitis B, hepatitis B, hepatitis B virus infection, hepatocellular cancer, pregnancy
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