February 19th, 2020

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Effect of Salpingectomy for Hydrosalpinx or Tubal Pregnancy on the Ovarian Reserve as Measured by Serum anti-Müllerian Hormone Levels
Authors:  Tomohiko Murase, M.D. , Akira Iwase, M.D., Ph.D., Michinori Mayama, M.D., Yasuyuki Kishigami, M.D., Hidenori Oguchi, M.D., Ph.D., and Fumitaka Kikkawa, M.D., Ph.D.
  OBJECTIVE: Salpingectomy is an established surgical intervention for tubal pregnancy and hydrosalpinx. However, there have been debates on whether this technique impairs ovarian reserve. The purpose of this study was to evaluate the influence of salpingectomy on ovarian reserve.

STUDY DESIGN: This prospective study recruited 36 women who underwent laparoscopic salpingectomy for tubal pregnancy and hydrosalpinx. Ovarian reserve was assessed by measuring preoperative and postoperative serum anti-Müllerian hormone (AMH) levels. We used the Wilcoxon test to compare preoperative and postoperative AMH levels and the Mann-Whitney test for comparing unilateral versus bilateral cases and tubal pregnancy versus hydrosalpinx cases.

RESULTS: The preoperative and postoperative median AMH levels were 2.26 ng/mL (interquartile range 0.90–4.19) and 1.97 ng/mL (interquartile range 0.77–3.91), respectively, without significant difference (p=0.944). No significant differences were found in the preoperative or postoperative AMH levels between the unilateral and bilateral cases, or in subjects with tubal pregnancy and hydrosalpinx.

CONCLUSION: Our results suggest that laparoscopic salpingectomy does not affect ovarian reserve during short-term follow-up after surgery.
Keywords:  anti-Müllerian hormone, hydrosalpinx, ovarian reserve, salpingectomy, tubal pregnancy
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