February 19th, 2020

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Schwannoma in Pregnancy Associated with Severe Preeclampsia and Maternal Mortality: A Case Report
Authors:  Sarah Colihan, M.D., Scott Dexter, M.D., and Craig Zelig, M.D.
BACKGROUND: Few case reports are available regarding spinal tumors in the setting of pregnancy. The association of schwannoma with maternal comorbidities such as preeclampsia and maternal mortality is not clear.

CASE: A 30-year-old woman, gravida 1 para 0, at 34+1 weeks’ gestation was admitted to labor and delivery with preeclampsia with severe features. Several days after delivery she was diagnosed with an 11-cm spinal mass. Biopsy confirmed the diagnosis of a schwannoma. Several days after biopsy she suffered a sudden right middle cerebral artery ischemic stroke. She died on postpartum day 24.

CONCLUSION: Pregnancy-related spinal tumors may be associated with multiple other comorbidities such as hypertension and stroke. Hormonal influences of pregnancy may accelerate spinal tumor growth.
Keywords:  adult; brain neoplasms; dyspnea; female; humans; hypertension; hypoxia; preeclampsia; pregnancy; pregnancy complications; spinal schwannoma; schwannoma; spinal cord neoplasms; spinal tumor; stroke
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