July 13th, 2020

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Mild Hyperbaric Oxygen Improves the Outcome of Infertility Treatment
Authors:  Fumihiko Yoshikawa, M.D., Ph.D., Yahiro Netsu, M.D., Tsuyoshi Shimizu, M.D., Ph.D., and Akihiko Ishihara, Ph.D.
  OBJECTIVE: Low metabolism in the uterus and/or ovaries may be a factor responsible for infertility because it reduces the ability of fertilized eggs to remain in the uterus. Exposure to mild hyperbaric oxygen can enhance oxygen supply to cells and tissues, thus improving metabolism. This study aimed to examine whether exposure to mild hyperbaric oxygen improves the outcome of infertility treatment.

STUDY DESIGN: Thirty-seven women (aged 39.3± 3.7 years) with intractable infertility who had previously received >5 embryo transfers with a low clinical pregnancy rate (4.9%) and without birth underwent several treatments of mild hyperbaric oxygen at 1,266 hPa with 36% oxygen before receiving an additional embryo transfer.

RESULTS: Thirteen women achieved clinical pregnancy, with the rate of 13.8%. Five women gave birth after in vitro fertilization treatment. Two women achieved natural conception and gave birth. One woman had an extrauterine pregnancy, and 5 women miscarried. Seven of 37 women who previously received >5 embryo transfers without birth underwent mild hyperbaric oxygen and gave birth naturally or with in vitro fertilization treatment.

CONCLUSION: Exposure to mild hyperbaric oxygen at 1,266 hPa with 36% oxygen is effective for improved outcomes of infertility treatment.
Keywords:  assisted reproductive techniques, dissolved oxygen, in vitro fertilization, infertility, metabolism, mild hyperbaric oxygen
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