July 13th, 2020

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miR-208a Induced Invasion and Migration of Human Trophoblast Cells Via Targeting CXCR4/PI3K/AKT Signaling Pathway in Preeclampsia
Authors:  Na Li, Ph.D., Ze-hui Yang, Ph.D., Fan-qing Li, M.D., Yu Lei, M.D., Si-rao Qu, Ph.D., and Man-man Zhao, M.D.
  OBJECTIVE: To investigate whether miR-208a affects the biological behavior and vascular development of trophoblast cells through CXCR4/PI3K/AKT signaling pathway.

STUDY DESIGN: This study used the human chorionic trophoblast cell line HTR-8 cells as the research object, combined with the changes in the invasion and migration ability of the cells, to explore the molecular mechanism of miR-208a involved in the development of preeclampsia.

RESULTS: Real-time PCR and western blot results showed a significant decrease in the relative expression of CXCR4 and PI3K and AKT mRNA in the miR-208a mimics transfected group. miR-208a may inhibit the activation of downstream PI3K/AKT signaling pathway by inhibiting the expression of CXCR4.

CONCLUSION: miR-208a can promote the invasion and migration of trophoblast cells, ultimately leading to the development of preeclampsia.
Keywords:  beta catenin, CXCR4/PI3K/AKT pathway, invasion, microRNAs, migration, miRNA- 208a, preeclampsia, pregnancy complications, RNA-binding proteins, signal transduction pathways, stem cells, transfection
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