July 13th, 2020

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Improvement of Clinical Pregnancy Rate of Frozen Embryo Transfer in Infertile Women with Thin Endometrium by Intrauterine Administration of Autologous Platelet-Rich Plasma During Endometrial Local Injury
Authors:  Ling Liu, M.D., Yanhua Zhou, M.Med., Xiaohan Wang, M.D., Zhiyan Xu, M.D., Xiangqing Hou, B.Med., Guangzhong Jiao, M.D., and Cuifang Hao, M.D.
  OBJECTIVE: To investigate whether autologous platelet-rich plasma infusion during endometrial local injury at thin endometrium in infertile women can avoid the cancellation of embryo transfer cycle caused by endometrial factors.

STUDY DESIGN: Eleven patients who had undergone previous frozen embryo transfer cycles were recruited into the study. After an endometrial local injury, autologous platelet-rich plasma (PRP) was infused into the uterine cavity at least once until endometrium thickness reached ≥7 mm.

RESULTS: The endometrium thickness of 10 patients was found to be ≥7 mm after PRP injection at time of endometrial local injury. Nine of those patients achieved pregnancy after embryo transfer.

CONCLUSION: PRP injection during endometrial local injury increased endometrial thickness and avoided the cancellation of embryo transfer cycle caused by endometrial factors.
Keywords:  assisted reproductive techniques, autologous platelet-rich plasma, endometrium, embryo transfer, endometrial local injury, platelet-rich plasma
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