July 13th, 2020

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Coexistent Marfan Syndrome, Seronegative Spondyloarthropathy, and Pregnancy- and Lactation-Associated Osteoporosis: A Case Report
Authors:  Erika P. Navarro, M.D., Mónica Urbano, M.D., Fabio Bonilla-Abadía, M.D., Gabriel J. Tobón, M.D., Ph.D., and Carlos A. Cañas, M.D.
BACKGROUND: Marfan syndrome and seronegative spondyloarthropathy (SpA) are diseases that generate skeletal abnormalities among other potential manifestations, with a genetic and inflammatory basis, respectively. Pregnancy- and lactation-associated osteoporosis (PLO) is a rare form of osteoporosis related to spine compression fractures during these periods of time.

CASE: A 24-year-old woman with a history of Marfan syndrome and SpA developed severe PLO, after 2 consecutive pregnancies, with multiple vertebral fractures and a significant spinal deformity. Potential pathogenic factors are exposed.

CONCLUSION: It is necessary to improve the recognition of PLO in order to ensure adequate genetic counseling, preventive measures, and treatment.
Keywords:  Bechterew syndrome, lactation, Mar-fan syndrome, Marie-Strumpell spondylitis, osteoporosis, pregnancy, pregnancy complications, spinal diseases, spondyloarthropathies, spondylarthropathy, spondyloarthropathy
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