February 19th, 2020

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Title:
Risk Factors for Cornual Heterotopic Pregnancy After in Vitro Fertilization and Frozen-Thawed Embryo Transfer
Authors:  Yitao Xiao, M.D., Qiuju Chen, M.D., Xuefeng Lu, M.D., Yun Wang, M.D., and Yanping Kuang, M.D.
  OBJECTIVE: To explore the risk factors for cornual heterotopic pregnancy after in vitro fertilization and embryo transfer (IVF-ET).

STUDY DESIGN: The clinical data of 22 patients with cornual heterotopic pregnancy after IVF-ET and 45 patients with tubal heterotopic pregnancy from July 2012 to December 2016 were retrospectively analyzed.

RESULTS: The proportions of cases with previous ectopic pregnancy, bilateral salpingectomy, and bilateral tubal interstitial occlusion in the cornual heterotopic pregnancy group were significantly higher than those in the tubal heterotopic pregnancy group (77.3% vs. 20%, 45.5% vs. 0, and 27.3% vs. 6.7%, respectively, p<0.05). The proportions of cases with unilateral salpingectomy, unilateral tubal interstitial occlusion, and bilateral hydrosalpinx in the cornual heterotopic pregnancy group were slightly lower than those in the tubal heterotopic pregnancy group, but the difference was not significant (p>0.05). The risk factors for cornual heterotopic pregnancy included previous ectopic pregnancy (OR 13.6 [3.950–46.82], p<0.01), bilateral salpingectomy (OR 76.44 [4.181–13.98], p<0.01), and bilateral tubal occlusion (OR 5.25 [1.17–23.56], p=0.0498).

CONCLUSION: The history of previous ectopic pregnancy, especially tubal pregnancy, salpingectomy, and tubal interstitial occlusion, are independent risk factors for cornual heterotopic pregnancy.
Keywords:  cornual heterotopic pregnancy; ectopic pregnancy; embryo transfer; hydrosalpinx; in vitro fertilization; previous ectopic pregnancy; risk factors; salpingectomy; tubal heterotopic pregnancy; tubal interstitial occlusion
   
   
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