September 27th, 2020

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Different Baseline Levels of Angiogenesis Related Cytokines in Serum of PCOS Patients With and Without Ovarian Hyperstimulation Syndrome Undergoing in Vitro Fertilization
Authors:  Zhen Hou, M.D., Ph.D., Reshef Tal, M.D., Ph.D., Chunxiang Wu, M.D., Yundong Mao, M.D., Ph.D., and Jiayin Liu, M.D., Ph.D.
  OBJECTIVE: To find new angiogenesis-related predictive biomarkers for ovarian hyperstimulation syndrome (OHSS) in polycystic ovary syndrome (PCOS) patients undergoing in vitro fertilization (IVF).

STUDY DESIGN: We collected serum samples at baseline from PCOS patients undergoing IVF who developed OHSS (n=5) or did not develop OHSS (n=5). Levels of 43 angiogenesis-related proteins were determined using a cytokine array.

RESULTS: In total, 15 cytokines had >1.5-fold change in serum of OHSS patients as compared with the control group (5 cytokines increased and 10 decreased). Serum levels of 5 cytokines were significantly different between the 2 groups. Interferon-inducible T cell alpha chemoattractant (I-TAC) was increased, while platelet-derived growth factor BB (PDGF-BB), placental growth factor (PLGF), transforming growth factor–β1 (TGF-β1), and thrombopoietin (THPO) were decreased in OHSS patients as compared with the non-OHSS group, respectively (p<0.05).

CONCLUSION: These results suggest that several previously unrecognized angiogenesis-related cytokines may play a role in the development of OHSS in PCOS patients.
Keywords:  angiogenesis; anovulatory infertility; assisted reproductive technologies; in vitro fertilization; infertility; IVF; OHSS; ovarian hyperstimulation syndrome; pathogenesis; PCOS; polycystic ovary syndrome
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