January 15th, 2021

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Ureaplasma Urealyticum Infection in the Genitourinary Tract in Pregnant Women with Premature Rupture of Membranes: An Analysis
Authors:  Yi Cao, M.D., Wei Chen, M.D., Zheng Hu, M.D., Ge Zhao, M.D., and Xin-hua Xie, M.D.
  OBJECTIVE: To quantify Ureaplasma urealyticum in the vaginal secretion of pregnant women with prelabor rupture of membranes (PROM) and to assess the effect of U. urealyticum antibody titer on pregnancy outcome.

STUDY DESIGN: The study included 235 pregnant women hospitalized at the obstetrics department for PROM from June 2015 to June 2016. The women were divided into 3 groups according to the measurement of U. urealyticum: study group with U. urealyticum antibody titer ≥104 colony-forming units (cfu)/mL (n= 70), U. urealyticum–positive group (n=25), and U. urealyticum–negative group (n=140). The maternal-fetal outcomes, including incidence of premature labor, percentage of low-birth-weight newborns, and the rate of amniotic fluid contamination, were compared.

RESULTS: The newborn birth weight of the study group was significantly lower than that of the U. urealyticum–negative group (p<0.05). The percentage of low-birth-weight newborns was 8.57% in the study group (6/70) vs. 4.29% (6/140) in the U. urealyticum–negative group. The incidence of premature labor was 17.14% in the study group (12/70) vs. 12% in the U. urealyticum–positive group (3/25) and 7.14% in the U. urealyticum–negative group (10/140). The rate of amniotic fluid contamination was 12.86% in the study group (9/70) vs. 12.86% in the U. urealyticum–negative group (18/140). Both study group and U. urealyticum–negative group showed an increased trend of amniotic fluid contamination rate as compared with the U. urealyticum–positive group (p>0.05).

CONCLUSION: The amniotic fluid contamination seemed not to be associated with U. urealyticum infection. U. urealyticum antibody titer ≥104 cfu/mL in the vaginal secretion for the pregnant women with PROM had poor pregnancy outcome.
Keywords:  amniotic fluid; amniotic fluid contamination; obstetric labor complications; low-birth-weight infant; mycoplasma infections; mycoplasma hominis; obstetric labor, premature; pregnancy; pregnancy complications, infectious; prelabor rupture of membranes; premature rupture of fetal membranes; Ureaplasma urealyticum
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